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What is CRP (C-reactive Protein) in a Blood Test?

CRP, or C-reactive Protein, is a substance the liver produces in response to inflammation. When there is inflammation in the body, CRP or C-reactive protein levels increase. A basic blood test known as a C-reactive protein test is conducted to check the CRP level in a body. 

This test will enable the identification of acute or chronic conditions causing inflammation, such as autoimmune disorders and infections. Continue reading this article to gain knowledge on CRP tests!

What Is a C-reactive Protein Test?

C-reactive protein or CRP is a type of protein produced by the liver. This protein is sent to the bloodstream as a response to inflammation. The C-reactive protein test is the measurement of the CRP level in an individual’s blood.

Generally, a person has a low C-reactive protein level in their blood. A high level of CRP might be a sign of severe infection or any other medical disorder.

What Is the Need for a C-reactive Protein Test?

The CRP test might be done in order to monitor the conditions which cause inflammation. These conditions include –

  • Bacterial infections like sepsis
  • Fungal infections
  • Inflammatory bowel disease
  • Autoimmune disorders such as rheumatoid arthritis and lupus
  • Osteomyelitis 

Furthermore, if an individual has already been diagnosed, this test also helps to monitor the treatment.

When Should I Get the C-reactive Protein Test?

If you have inflammation symptoms such as swelling, fever of unknown origin, and pain, among others, then it is important to consider having a C-reactive protein (CPR) test. It is also used to monitor the course of chronic inflammatory conditions like rheumatoid arthritis or inflammatory bowel disease.

In addition, CRP testing may be performed to screen for infection and frame out your heart disease risk. Doctors may also use CRP levels to monitor recovery after treatment or surgery, offering insights into potential complications.

What is the Procedure for the C-reactive Protein Test?

Usually, this examination requires drawing about 5 millilitres of blood from a vein in an arm. This sample will then be sent to a laboratory, where it will be analysed by looking at the level of C-reactive proteins found within your bloodstream.

The test is very simple; it takes just a few minutes, and you do not have to prepare anything special. This technique is least invasive, and blood drawing discomforts are usually transient.

How to Prepare for a C-reactive Protein Test?

Avoid doing strenuous excesses like a long run or intense weight training before the test. In case your blood is used for additional tests, the doctor might recommend you stop eating certain foods before a CRP test. Furthermore, certain medicines affect the CRP level.

Make sure to tell your doctor about the medications, supplements, or herbal remedies you take before the test. Adhering to these directions will ensure that your CRP measurements are accurate and, hence, a better understanding of your health status.

How is C-reactive Protein Measured in Blood Tests?

The quantity of CRP in your bloodstream can be determined using a blood test that directly measures its levels. A healthcare practitioner draws blood from your arm’s vein to perform the test. The collected specimen is then transported to the laboratory, where sophisticated equipment is used for analysis.

Laboratory reports give concentration results in terms of mg/L (milligrams per litre). Elevated levels indicate an ongoing body inflammation or infection. It is frequently used for assessing disease activity and responses to treatment.

How to Read the Results of the C-reactive Protein Test?

Generally, the result of a CRP test is measured in mg/dL or mg/L. In most cases, the doctor will explain to you the results of the test; however, in general:

CRP Levels Meaning of the Results
Less than 6 mg/L Normal CRP level in a healthy body
3 to 10 mg/L Normal to moderate inflammation
10 to 100 mg/L Inflammation in the whole body due to bronchitis, autoimmune disease, pancreatitis, cancer or heart attack
Over 100 mg/L Inflammation in the whole body due to acute viral infections, acute bacterial infections, major trauma, or systemic vasculitis
Over 500 mg/L Severe inflammation in the whole body because of severe bacterial infections

Normal Range of C-reactive Protein in a Blood Test

Most people will have CRP levels between 0 and 10 mg/L, which is normal for all age groups, including adults, children, and infants. If CRP is elevated, then it could be indicative of inflammation or infection, whereas when it falls within this range, most likely, there isn’t any significant inflammatory condition.

Group Normal Range (mg/L)
Adults, Children, Infants 0 - 10 mg/L

Symptoms of High C-reactive Protein

High body levels of CRP mean a person has an inflammatory condition or an infection. Symptoms that may be associated with high CRP include:

Symptom Description
Fever An increased body temperature usually signifies an immune response to inflammation, which can also come with chills, sweating, and higher CRP to fight infections.
Pain When you experience pain with high levels of CRP, it is usually due to inflammation. It may vary from sharpness to dullness and be localised in areas affected by inflammation.
Swelling Swelling occurs because more fluid accumulates in tissues caused by inflammation; this can be seen in joints or limbs, causing discomfort or tenderness.
Redness Redness occurs in areas of inflammation due to increased blood flow and dilatation of blood vessels. This sign is commonly observed during skin infections or acute inflammation.
Fatigue Tiredness is a common symptom experienced when one has high levels of CRP because the body's inflammatory response disrupts normal energy levels.
Loss of Appetite High CRP levels may decrease appetite. This can lead to unintended weight loss and be connected with overall body inflammation or other underlying health problems.
Joint Stiffness Inflammation often leads to joint stiffness. It can limit movement and flexibility, especially in rheumatoid arthritis or other inflammatory diseases associated with joints.
Shortness of Breath High levels of CRP may cause shortness of breath due to respiratory inflammation. It affects respiration efficiency and is a potential indicator of lung or airway problems.

What Happens If C-reactive Protein Level Is High?

Elevated CRP level can be a sign of infection, cancer, inflammatory bowel disease, rheumatoid arthritis, lupus and tuberculosis. Furthermore, it can also lead to atherosclerosis, coronary artery disease, heart attack, failure or stroke.

Persistent high CRP levels may indicate ongoing inflammation or chronic disease, which could require further investigation and management. Regular monitoring and appropriate treatment are crucial to address the underlying causes and prevent complications.

CausesWhat are the Causes of High C-reactive Protein?

High CRP levels can be caused by a range of conditions that trigger inflammation in the body. Common causes include:

Cause

Description

Infections

Inflammatory reactions resulting from bacterial, viral, or fungal infections are known to trigger increased concentrations of C-reactive protein in the body. 

Chronic Diseases

Chronic conditions such as rheumatoid arthritis/lupus have ongoing inflammations, resulting in normal values of CRP remaining constantly high. 

Autoimmune Disorders

When an individual's immune system attacks healthy body tissues, leading to inflammation and raised blood-CRP levels, this is called an autoimmune disease. 

Injuries

Physical injuries may lead to localised swelling and tissue damage, elevating CRP. Rising levels of CRP signify the body's response to the repairing and healing process.

Cancer

Inflammation or tissue injury accompanying tumour growth, cancer treatments, or cancer-related inflammation could explain the high levels of CRP in some malignancies.

Obesity

Chronic low-level inflammation caused by excessive fat deposits, mainly on the belly, can raise CRP levels. This is part of a systemic inflammatory reaction seen across various chronic conditions.

Chronic Kidney Disease

CRP levels may be raised when there is kidney dysfunction or chronic kidney disease. Among other things, the kidneys are also involved in filtering and regulating markers of inflammation.

Cardiovascular Diseases

Inflammation in the blood vessels and heart muscles due to conditions such as hypertension and heart disease can cause increased CRP levels. 

What to Do If C-reactive Protein Is High?

Before proceeding, it is very important to know that lowering the CRP is not guaranteed to reduce the risk of autoimmune or cardiovascular disease.

Eating a nutritious and balanced diet that consists of fibre, fruits and vegetables can help lower the CRP concentration. Moreover, your doctor might suggest medications like statin or cholesterol-reducing medicines to reduce the CRP level. Vitamin C is also a way to reduce the CRP level for individuals with higher odds of cardiovascular diseases.

Furthermore, the preventive measures mentioned below can help you lower the C-reactive protein levels in your body –

  • Increase aerobic exercises such as running, cycling or fast walking
  • Quit smoking
  • Lose weight
  • Consume a heart-healthy diet

Therefore, individuals experiencing any changes, symptoms, or discomfort should talk to their doctor immediately. People sometimes confuse the C-reactive protein test with the high-sensitivity CRP test. Though both of these tests measure the CRP level in the body; however, the tests are done to identify different medical conditions.

What If CRP is Low?

Generally, if C-reactive protein is low, this indicates a good sign of little or no inflammation in the body. This often means you are healthy as CRP increases during inflammations, infections, and other chronic diseases.

However, CRP is mainly meant to diagnose inflammation; hence, a low level does not mean that there are no health complications but rather shows that significant inflammatory processes may be absent. Therefore, always refer to your healthcare provider for further explanation about your CRP results regarding your particular situation.

Therefore, individuals experiencing any changes, symptoms, or discomfort should talk to their doctor immediately. People sometimes confuse the C-reactive protein test with the high-sensitivity CRP test. Though both of these tests measure the CRP level in the body, the tests are done to identify different medical conditions.

FAQs about C-reactive Protein in Blood Tests

What does high CRP mean?

A high CRP level means an increased risk of inflammation. It also indicates inflammation in arteries and high chances of a heart attack.

When should a person test the CRP level?

Individuals having a medical history and experiencing the symptoms of severe bacterial infection must get their CRP level tested.

What is the purpose of a CRP test?

This test determines whether your blood has C-reactive protein (CRP), which can show if you have an infection, chronic disease, or autoimmune disorder.

How is a CRP test performed?

The doctor will draw a small blood sample from a vein typically in your arm. Afterward, it will be taken to a laboratory where they will analyse it to determine how much C-reactive protein is present.

What does a low CRP level indicate?

Usually, a low CRP level indicates no or little inflammation in the body, which is generally an indicator of good health.

Can CRP levels fluctuate?

Yes, depending on factors like infection, injury, or chronic inflammatory diseases, CRP levels can fluctuate. Additionally, they vary in response to medication and treatment.

Is fasting required before a CRP test?

Generally, you do not need to fast before conducting a CRP test. Nonetheless, follow any specific guidelines given by your doctor.

What other tests might be ordered along with a CRP test?

Doctors may also order other tests such as ESR (erythrocyte sedimentation rate), CBC (complete blood count), or condition-specific investigations to provide a holistic view alongside the CRP test.

How often should I get a CRP test?

The frequency of performing CRP tests will depend on your medical condition and treatment plan. Your healthcare provider will advise you on how often you should go for the test based on your unique health needs.

Can medications affect CRP levels?

Yes, there are some medications like anti-inflammatory drugs and statins that lead to reduced levels of CRP. Make sure that your physician knows all this information.

What should I do if my CRP level is abnormal?

If abnormal results occur for the level of C-reactive protein, necessary considerations include discussing with your healthcare practitioner what has caused it and possible therapies or next steps for monitoring.

Does CRP testing help in diagnosing specific diseases?

CRP testing only aids in detecting inflammation; it is not disease-specific. It is combined with other clinical appraisals and tests to diagnose and monitor illnesses.

Can lifestyle changes impact CRP levels?

Yes, lifestyle changes such as improving diet, increasing physical activity, and managing stress can help reduce CRP levels and inflammation.

Are there any risks associated with the CRP test?

The CRP test is generally safe with minimal risks. The most common issue is slight discomfort from the blood draw, but serious complications are rare.