Entamoeba histolytica, a one-celled parasite, is the source of the condition known as amoebiasis. People who contact Entamoeba histolytica protozoan get amoebiasis disease. Also, Amoebiases are present everywhere; however, their prevalence is significantly higher in the tropics and subtropics.

Amoebiasis is an intestinal disease that happens because of harmful pathogenic species, and species that attack the colon innocuously, are morphologically identical.

Amoebas attach to colonic cells, consume them, and then produce dysentery, which results in blood and mucus in the stool. Additionally, amoebas emit compounds known as proteases that weaken the colon's lining and allow invasion into the intestinal wall and beyond.

The majority of those who have amoebiasis do not exhibit symptoms. However, symptoms may appear seven to twenty-eight days after being introduced to the parasite.

Mild amoebiasis symptoms could consist of the following:

• Diarrhoea: 3 to 8 semi-formed stools per day or soft stools with mucus and sporadic blood
• Stomach pains
• Fatigue
• Rectal discomfort during a bowel movement (tenesmus)
• Bloating
• Unintentional loss of weight

Severe signs could include:

• Tenderness of abdomen
• 10 to 20 bloody stools per day, including the passing of liquid stools with blood streaks.
• Fever
• Vomiting

Typically, E. histolytica enters the body when an individual consumes cysts in food or water. However, it may also come into touch with faeces and then enter the body directly.

• The parasite's relatively dormant cysts can survive for several weeks in the environment or soil where they were dispersed in faeces. Therefore, the small cysts can be found in water, fertiliser, or soil that has come into contact with tainted excrement.
• When handling or preparing food, food handlers are at risk of spreading cysts. Additionally, transmission is possible during colonic irrigation and coitus. 
• Cysts that enter the body settle in the digestive system. The parasite's invasive, active form, known as a trophozoite, is then released. Also, these parasites multiply in the gastrointestinal system before moving to the large intestine. They have the ability to tunnel into the colon or intestinal wall there.

Although everyone can get this illness, it most frequently affects residents of impoverished nations with unsatisfactory hygienic conditions. As a result, amoebiasis is more frequently detected in immigrants from developing nations in developed countries. Additionally, it can be detected in people who have visited underdeveloped nations and in residents of unhygienic institutions.

Some additional risk factors include:

• Cancer
• Alcohol use
• Malnutrition
• Pregnancy
• Younger or older age
• Consumption of corticosteroid medicine
• Travel to a tropical country

The most frequent test used to make a diagnosis is a stool examination. In this regard, trophozoites are a diagnostic finding. However, pus and white blood cells are frequently visible, too.

• For a conclusive diagnosis, at least three fresh stool samples must be studied because trophozoites are quickly eliminated by drying or water. Additionally, a concentrated stool or fresh stool examination is positive in 75% and 95% of patients.
• Also, a blood test is available, and more than 90% of individuals with invasive amoebiasis get positive results. But, due to the risk of perforation, barium tests are not advised in cases of acute amoebic colitis.
• Hepatic amoebiasis can be identified by abdominal ultrasonography, MRI and CT scans. However, in the follow-up, clinical response is more significant than repeated scans since abscesses heal slowly or may even get bigger while being treated.
• It is essential to distinguish between acute intestinal amoebiasis and the bacteria that cause inflammatory bowel disease and traveller’s diarrhoea (caused by Escherichia coli).

Usually, symptoms of amoebiasis are reduced by general therapy, which also replenishes blood and restores fluid and electrolyte balance. Antibiotics such as Metronidazole must be taken for five days for amoebic dysentery. Also, they must be taken for 10–14 days if there is an extraintestinal spread or liver abscess.

Furthermore, with amoebiasis treatment, large liver abscesses may need to be drained, and an ultrasound scan can be used to pinpoint the abscess’s precise location and place the drainage needle.

Being cautious about what you consume, particularly in developing countries, can help prevent this infection. This is because amoebas may contaminate food and water.

However, a decent rule of thumb for food in such regions is to cook, peel, or boil. You can also avoid ice in these nations as it may also be contaminated. Additionally, washing your hands after using the restroom and before eating or preparing food would be best.

Amoebiatic Colitis Complications

The complications one will face are

• Toxic megacolon
• Recto vaginal fistula
• Necrotising colitis
• Amoeboma

Amoebic Liver Abscess Complications

Under this, one may face

• Intrapericardial, intraperitoneal or intrathoracic rupture without or with secondary bacterial attack
• Extension to pericardium or pleura
• Brain abscess

Other Complications

People may also face

• Peritonitis
• Empyema
• Stricture formation

You must consult a doctor if you are exhibiting any amoebiasis signs or symptoms. Some warning signs include:

• Gastrointestinal bleeding or mucus
• More than two-week-long diarrhoea
• Stomach discomfort
• Fever
• Bloated stomach or tenderness around the liver

In underdeveloped nations or subtropical and tropical zones, amoebiasis is endemic. However, it manifests as an imported infectious disease in wealthy nations. Fortunately, treatment for amoebiasis often works effectively, and it should go away in approximately two weeks. Nevertheless, amoebiasis disease can be fatal if left untreated.